In vitro Comparison of Metronidazole and Tinidazole Activity against Trichomonas vaginalis Strains in Maiduguri, Nigeria
H. S. Hamafyelto *
Department of Medical Microbiology, Faculty of Medical Sciences, University of Jos, P.M.B. 2084, Jos, Plateau State, Nigeria
I. E. Ikeh
Department of Medical Microbiology, Faculty of Medical Sciences, University of Jos, P.M.B. 2084, Jos, Plateau State, Nigeria
O. V. Oladele
Department of Medical Microbiology, Faculty of Medical Sciences, University of Jos, P.M.B. 2084, Jos, Plateau State, Nigeria
*Author to whom correspondence should be addressed.
Abstract
This study investigated the in vitro comparison of metronidazole and tinidazole activity against Trichomonas vaginalis strains from internally displaced women in Maiduguri, Nigeria. Materials and Methodology: high vaginal swab samples were collected from (41) T. vaginalis positive women who consented for the study was cultured and isolated. The results were analyzed using SPSS statistics version 20.0. Results recorded (53) T. vaginalis strains for metronidazole with minimum inhibitory concentration (MIC) range from 0.4 - 25 μg/ml and low-level resistance strains to metronidazole observed 3.8% at 25.0 μg/ml with minimum latent concentration (MLC) ≥ 50.0 μg/ml. Forty-nine (49) T. vaginalis strains were observed on the MIC range from 0.4 µg/ml to 12.5 µg/ml, indicating that all strain isolates were susceptible to tinidazole at above 12.5 μg/ml MLC. This study showed in vitro low resistance to metronidazole in a few T. vaginalis strains, while all the tested isolates were sensitive to tinidazole.
Keywords: In vitro, Trichomonas vaginalis, metronidazole and tinidazole, Nigeria