Intralipid in the Target Treatment of Lipid Peroxidation Disorder Caused by Oxidative and Nitro- Galogenic Stress in Patients with SARS-Cov2 / COVID / 19

Main Article Content

Maria Vasilieva
Irina Vasilieva
Ilie Vasiliev
Stanislav Groppa
Gh. Ghidirim
Mircea Bețiu
Valentina Diug
Nicolae Bacinschi
Eugen Diug
Olga Tagadiuc
Pavel and Tanea Globa
Ninel Revenco
Gheorghe Plăcintă
Lorina Vudu
Jana Bernic
Gheorghe Caradja
Lilian and Elena Globa
Serghei Ignatenco
Ludmila Serbenco
Andrei Cealan
Mirta D'Ambra
Oleg Tarabrin

Abstract

Background: In the current proposal, we used the intralipid in standard therapy against COVID / 19 as an energy carrier for parenteral nutrition in critically ill patients. In patients receiving intralipid, there was an accelerated recovery of the lungs, a decrease in markers of endogenous intoxication (EI), tissue hypoxia and an improvement in general condition. In the absence of Intralipid in the intensive care unit, there was a slow recovery of the lungs and a more prolonged improvement in the general condition with the preservation of EI markers (cytolytic enzymes, C-reactive protein, platelets) and tissue hypoxia (pCO2 AV> 6 mm Hg). Collectively, Intralipid has been seen in the targeted LPO treatment plan for oxidative and nitro-galogenic stress in SARS-Cov2 / COVID / 19 patients.

Keywords:
Intralipid, syndrome of maria&Irina vasilieva, SARS-Cov2/COVID/19, reactive oxygen species, reactive nitrogen species, oxidative and nitro-galogenic stress.

Article Details

How to Cite
Vasilieva, M., Vasilieva, I., Vasiliev, I., Groppa, S., Ghidirim, G., Bețiu, M., Diug, V., Bacinschi, N., Diug, E., Tagadiuc, O., Globa, P. and T., Revenco, N., Plăcintă, G., Vudu, L., Bernic, J., Caradja, G., Globa, L. and E., Ignatenco, S., Serbenco, L., Cealan, A., D’Ambra, M., & Tarabrin, O. (2020). Intralipid in the Target Treatment of Lipid Peroxidation Disorder Caused by Oxidative and Nitro- Galogenic Stress in Patients with SARS-Cov2 / COVID / 19. Journal of Advances in Medical and Pharmaceutical Sciences, 22(11), 20-30. https://doi.org/10.9734/jamps/2020/v22i1130202
Section
Original Research Article

References

Eldor J. Can the last protocol be used as a coronavirus protocol? Linkedin; 2020.
Available:https://www.linkedin.com/pulse/can-last-protocol-used-coronavirus-joseph-eldor/

Eldor J. Can Intralipid (lipid emulsion) inactivate the coronavirus? Someone in china must to test it! Linkedin; 2020.
Available:https://www.linkedin.com/pulse/can-intralipid-lipid-emulsion-inactivate-coronavirus-someone-eldor/

Eldor J. Can Intralipid (lipid emulsion) inactivate the coronavirus? Linkedin; 2020. Available:https://www.linkedin.com/pulse/can-intralipid-lipid-emulsion-inactivate-coronavirus-joseph-eldor/

Eldor J. Can Intralipid (lipid emulsion) inactivate the coronavirus? Linkedin; 2020. https://www.linkedin.com/pulse/can-intralipid-lipid-emulsion-inactivate-coronavirus-joseph-eldor-1e/

Eldor J. Intralipid (lipid emulsion): A novel lipid-based branch of antiviral research - It MUST be Clinically tested NOW. Linkedin; 2020.
Available:https://www.linkedin.com/pulse/intralipid-lipid-emulsion-novel-lipid-based-branch-antiviral-eldor/

Eldor J Can. Intralipid (lipid emulsion) inactivate the coronavirus? Linkedin; 2020. Available:https://www.linkedin.com/pulse/intralipid-lipid-emulsion-novel-lipid-based-branch-antiviral-eldor/

Eldor J, Nguyen T.A, Nguyen K.T, et al. Intralipid is a magic bullet; 2018. Available:https://www.smashwords.com/books/view/843448

Javid MJ, Zebardast J. Rescue therapy with intralipid for pulmonary complications of Covid 19: A new approach. Austin J. Anesthesia and Pain Relief. 2020;8(2):1087.

Vasiliev I, Vasilieva M, Vasilieva I, Catereniuc I, et al. The extracorporeal bio-xeno perfuzion (myelo-timo-spleen) in multi-organ suportive therapy (MOST) as a modulator of energy, for immuno corection compensatory anti-inflamatory respons sindromes, and persistent inflammation, imunno supression, catabolism, and multi organ dysfunction. J Anesth Patient Care; 2015;1:1045.
DOI: 10.15744/2456-5490.1.104

Vasiliev I, Vasilieva M, Vasilieva I, Catereniuc I, et al. Aggressiveness syndrome hyperantiinflammatory immune chaos dissonance and extracorporeal myelotimospleen perfusia. Tolyatti Med Counc; 2016;3-4:64-7.
Available: https://www.elibrary.ru/item.asp?id=27208738

Vasiliev I, Vasilieva Maria, Vasilieva Irina, Ghicavii V, et al. The recruitment of microcirculatory-mitochondrial of critical obstetric situations in the complex multi-organ support therapy reduces pCO2 (AV gap) and the development of the syndrome of acute multi-organ dysfunction. Journal of Genetic Disorders; 2020.
DOI: 10.21767/2471-8084-C1-022.
Available:https://www.imedpub.com/scientific-journals-list/top-open-access-social-media-journals-1244.html

Vasiliev I, Vasilieva Maria, Vasilieva Irina, Ghicavii V, et al. The recruitment of microcirculatory-mitochondrial of critical obstetric situations in the complex multi-organ support therapy reduces pCO2 (AV gap) and the development of the syndrome of acute MODs. Biochem Mol Biol J. 2019; 5:22.
DOI: 10.21767/2471-8084-C1-022
Available:https://www.imedpub.com/scientific-journals-list/antibiotic-production-peerreview-journals-5470.html

Available:https://www.imedpub.com/conference-abstracts/keynote/biotechnology-biomarkers-systems-biology-2019-proceedings.html

Available:https://www.imedpub.com/proceedings/the-recruitment-of-microcirculatorymitochondrial-of-critical-obstetric-situations-in-the-complex-multiorgan-support-ther-6818.html

Available:https://www.imedpub.com/conference-abstracts-files/2471-8084-C1-022-001.pdf

Vasiliev I, Vasilieva Maria, Vasilieva Irina, Ghicavii V, Litarczek G, Friptu V. The recruitment of microcirculatory-mitochondrial of critical obstetric situations in the complex multi-organ support therapy reduces pCO2 (AV gap) and the development of the syndrome of acute multi-organ dysfunction. Genetics and Molecular Biology Research; 2020.
DOI: 10.21767/2471-8084-C1-022
Available:https://www.imedpub.com/scientific-journals-list/dna-sequencing-technologies-highimpact-journals-16120.html

Irina Vasilieva, Maria Vasilieva, Vasiliev I*, Groppa S, et al. Role of pCO2 (AV gap) of multi organ dysfunction syndrome. J Biomed Pharm Sci. 2019;2:2.

Corpus ID: 216118775
Available:https://www.hilarispublisher.com/open-access/role-of-pco2-av-gap-of-multi-organ-dysfunction-syndrome.pdf

Maria Vasilieva, Irina Vasilieva I, Vasiliev M, Malakhova, et al. Electro - Ion membrane distress syndrome induces chronic fatigue syndrome/ myalgic encephalomyelitis (CFS/ME). ResearcheGate. Berlin. Germany; 2020.
Available:https://www.researchgate.net/publication/341781287_Electro_-Ion_Membrane_Distress_Syndrome_induces_Chronic_Fatigue_SyndromeMyalgic_Encephalomyelitis_CFSME

Maria Vasilieva, Irina Vasilieva I, Vasiliev M, Malakhova, et al. L'importance du sindrom maria&irina vasilieva (syndrome de détresse de la membrane électro-ionique) dans le développement du syndrome CFS/ME. Publiched on Linkedin. WAMS; 2020.

Maria Vasilieva, Irina Vasilieva I, Vasiliev M, Malakhova, et al. Electro-Ion membrane distress syndrome induces chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). J Clin Res Anesthesiol. 2019;2:1:1
Available:https://asclepiusopen.com/journal-of-clinical-research-in-anesthesiology/volume-2-issue-2/3.pdf

Vasilieva Irina, Vasilieva Maria I, Vasiliev V, Ghicavii, et al. Triphosphoric acid, donated, restores heart rhythm disturbances caused by energetically deficient, mitochondrial hypercalcaemia to Ca++ mpt pore lesion. J Clin Res Anesthesiol. 2018;1:1-3.
Available:https://asclepiusopen.com/journal-of-clinical-research-in-anesthesiology/volume-1-issue-2/6.pdf

Irina Vasilieva. Genetic aspects of addiction. Public Health Chronicle. Journal of the State Public Health Surveillance Service. 2018;1(46):9-10.
Available:https://ansp.md/wp-content/uploads/2014/06/nr1_CSP.pdf

Vasilieva I. Genetic aspects of addiction. Mol Biol Human Gen. 2016:1-9.
Available:https://usmf.md/wp-content/uploads/2016/10/Program-Invita%C5%A3ie-Conferinta-Anuala-20161.pdf

Vasiliev I. Biotechnology, biomarkers & systems biology 2019: Mitochondrial of critical obstetric situations in the complex multi-organ support therapy reduces pCO2 (AV gap) and the development of the syndrome of acute multi-organ. Scholars Research Library J. of Computational Methods in Molecular Design; 2020.
Available:https://www.scholarsresearchlibrary.com/abstract/biotechnology-biomarkers-systems-biology-2019-mitochondrial-of-critical-obstetric-situations-in-the-complex-multiorgan-s-48117.html

Vasiliev I. Mitochondrial of critical obstetric situations in the complex multi-organ support therapy reduces pCO2 (AV gap) and the development of the syndrome of acute multi-organ dysfunction. World Academy of Medical Sciences. WAMS' International Medical Research Council (IMREC). J. of Computational Methods in Molecular Design. 2020;10:2.

D’Ambra M, Vasiliev I, Shevcenko V. When the trauma is serious. Am J Biomed Sci Res. 2019;2:241.
DOI: 10.34297/AJBSR.2019.02.000616
Available:https://biomedgrid.com/search-articles.php

Diug V, Vasiliev I. Definitive haemostasis in hematoma postpartum massive hemorrhage sum of summaries. romania, Iasi: National Conference. 2018;44-6.
Available:http://www.radioiasi.ro/wp-content/uploads/sites/6/2018/04/ZileleDobrovici_site-aprilie-2018.pdf

Vasiliev I, Creciun A. Cases of anaphylactic shock and tactics emergency therapy. Courr Med. 1986;5:51-3.

Vasiliev I, Calalb I, Bujujan A, Cacian M. Successful treatment of disseminated intravascular cagulation syndrome in obstetrics. Actual Problems Anesthesiology and Intensive Therapy. Arkhangelsk: 2nd White Sea Symposium. 2007;106-8.
Available:http://www.anesth.ru/CONTENT/BEL%20SYMPOSIUM/BS-ABSTRACTS.pdf

Vasiliev I, Ceban N. The lymphotropic therapy with lymph stimulation in complex treatment of exotoxin shock. Health Care. 1989;2:53-4.

Vasiliev I, Solodkin S, Nistor V, Bogdan V. The extracorporeal bio-xeno perfusion as a complex therapeutic component of the treatment of septicemia on the background of associated injury. Courr Med. 1993;2:56-9.

Vasiliev I, Malachi M, Niculita I. The extracorporeal bio-xeno perfusion (timo-spleen) for the complex treatment of systemic lupus erythematosus. Courr Med. 1996;2:41-3.

Ignatenco S, Vasilieva Irina, Crăciun I. Temporary closure of the abdominal cavity in patients undergoing mesenteric ischemia. E-Poster. Congress dedicated the 75th anniversary of the founding of the State University of Medicine and Pharmacy "Nicolae Testemițanu". October 21-23. Chisinau. 2020;39
Available:https://usmf.md/sites/default/files/inline-files/PROGRAM_16.10.2020-PROIECT-.pdf

Available:http://repository.usmf.md/bitstream/20.500.12710/12697/1/INCHIDEREA_TEMPORARA_A_CAVITATII_ABDOMINALE_LA_PACIENTII_OPERATI.pdf

Vasiliev I, Vasilieva M, Vasilieva I. The medico legal indications and contraindications to the use ECMO and ECCO2R at Ali/Ards. United States: Project Proposed for Discussion and Study Wams. 2016;6-9.

Vasiliev I. Respiratory support with alveolar recruitment for complex treatment of acute lung injury and acute respiratory distress syndrome. Krasnoyarsk: International Congress for Respiratory Support. 2009;2-7.

Irina Vasilieva, Maria Vasilieva I. Vasiliev M. Malakhova, et al. Maria & irina vasilieva syndrome contributes to the manifestation of chronic fatigue syndrome/ myalgic encephalomyelitis syndrome (CFS / ME). E-Poster. National Congress of UroGynecology. "Vasile Dobrovici" Medical Days - November 26-28 - exclusively online. Iași. Romania. 2020;14.
Available:https://zd-urogin2020.medical-congresses.ro/

Vasiliev Ilie, Vasilieva Irina, Vasilieva Maria. Prevention of the development of multi organ dysfunction syndrome-is achieved by complex methods of recruiting microcirculatory-mitochondrial distress syndrome, in which the pCO2 (AV gap) Increases. Austria: Éditions Universitaires Européennes; 2019.

Vasiliev I, Vasilieva M, Vasilieva I, Litarczek G, Friptu V, Gladun S. Suspending microcirculatory-mitochondrial distress syndrome by recruiting microcirculatory-mitochondrial disorders of obstetric critical situations. Iasi, Romania: National Congressional Society of Obstetric and Gynecological Society of Romania Sum of Summaries. 2018; 167.

Vasiliev I, Vasilieva M, Vasilieva I, Litarczek G, et al. Suspending microcirculatory-mitochondrial distress syndrom by recruiting microcirculatory-mitocondrial disorders of obstetric critical situations. E-poster. Iasi, Romania: National Congressional Society of Obstetric and Gynecological Society of Romania, Sum of Summaries. 2018;41.

Vasiliev I, Maria V, Irina V, Ghicavii V, et al. The recruitment of microcirculatory-mitochondrial of critical obstetric situations in the complex most reduces pCO2 (AV gap) and the development of the syndrome of acute MODs. Amsterdam: Proceeding of International Conference on Biotechnology, Biomarkers and System Biology. Session Chair Vasiliev Ilie, Keynote Presentation. 2019;22.
DOI: 10.21767/2471-8084-C1-022
Available:https://www.imedpub.com/conference-abstracts-files/2471-8084-C1-022-001.pdf

Vasiliev I., Vasilieva M. Vasilieva I, Litarczek G, et al. De-instalation of the MODs by associating the microcirculatory-mitochondrial recruitment with most in ELSO. Perinatology Bulletin. Journal of Research Practice Suppliment. Chişinău: VI National Congress of Obstetrics ang Ginecology with International Participation. 2018;3:6.
Available:https://ru.scribd.com/document/391903001/Buletin-de-Perinatologie-Supliment

Vasiliev I, Vasilieva M, Vasilieva I. Recruitment of microcirculatory-mitochondrial of critical obstetric situations in the complex of most stops the development of the MODs. Barcelona, Spain: Global Summit on Medicine, Pharmacology and Cancer Research with WAMS; 2018.

Vasiliev I, Vasilieva M, Vasilieva I. Recruitment of microcirculatory-mitochondrial of critical obstetric situations in the complex of most. Chisinau: IV National Obstetric Congress with International Participation. Republic of Moldova. 2018;14.
Available:https://obstetrica.usmf.md/en/node/18764

Moldovan I, Vasilieva Maria, Odobescu S, Rotaru L. Altered state of consciousness-possible factor of amplification of the therapeutic effect of neurostimulation in chronic pain. Bull Acad Sci Moldava Spec ed. 2018;1-6.
Available:https://stiinta.usmf.md/sites/default/files/inline-files/Raport%20USMF%202018%20final.pdf

Vasilieva Maria. The role of modified consciousness in the possibility of neuro-stimulation treatment in chronic pain. Moldova: Days of the State University of Medicine and Pharmacy Nicolae Testemitanu. 2018;47.
Available:https://stiinta.usmf.md/sites/default/files/inline-files/_%20%20Programul%20Conferin%C5%A3ei%20%C5%9Ftiin%C5%A3ifice%20anuale%2C%2017-19%20octombrie%202018%20.pdf

Vasilieva Maria. Altered state of consciousness as a possible factor to amplify the therapeutic effect in the case of neurostimulation in the chronic pain. Chisinau: Scientific Adviser MD, PhD, Professor, Department of Neurology Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova Association of Medical Students and Residents Abstract Book MedEspera 2018 The 7th International Medical Congress for Students and Young Doctors May 3-5, Universul” 2018;56.
Available:https://medespera.asr.md/wp-content/uploads/Abastract-Book-2018.pdf

D’Ambra M, Vasiliev I, Karindas M. Small brain vessels disease. Biomed J Sci Technol Res. 2019;19:14555-6.
DOI: 10.26717/BJSTR.2019.19.003355
Available:https://biomedres.us/fulltexts/BJSTR.MS.ID.003355.php

Maria V, Irina V, Vasiliev I, Groppa S, et al. Neurovegetative correction of diencephalic-hyperkinetic, catabolic adrenergic syndrome. J Clin Res Anesthesiol. 2018;1:1-3.
Available:https://asclepiusopen.com/journal-of-clinical-research-in-anesthesiology/volume-1-issue-2/5.pdf

Călcâi Cornelia, Hadjiu Svetlana, Revenco Ninel, Vasilieva Maria. Evolutionary peculiarities of stroke in young children following cranio-cerebral trauma. Bull Acad Sci Mold. 2017;2; 54:320-3.
Available:http://old.asm.md/administrator/fisiere/editii/f54.pdf

Vasilieva Maria, Rîbac Nicolae, Țurcanu Vitalie. Strokes in young children, clinical case (scientific advisory - MD Cornelia Călcîi, associate professor, Department of Pediatrics). “Nicolae Testemitanu” State University of Medicine and Pharmacy. The annual scientific conference, dedicated to the 90th anniversary of the birth of the illustrious Professor and scientist Nicolae Testemitanu. 2017;41:16-20.
Available:https://usmf.md/wp-content/uploads/2014/10/Program-invita%C5%A3ie-Conferinta-stiintifica-anuala-2017-versiunea-2-1.pdf

Vasilieva Maria. Cerebral intestinal microbiome axis (scientific advisory – Academician. Professor PhD Stanislav Groppa, Head of the Neurology Department no. 2 “Nicolae Testemitanu” State University of Medicine and Pharmacy). 2019;48.
Available:https://stiinta.usmf.md/sites/default/files/inline-files/2019%20Programul%20Conferin%C5%A3ei%20%C5%9Ftiin%C5%A3ifice%20anuale%2C%2016-18%20octombrie.pdf

Vasilieva Maria. Epileptic seizures - primary manifestation in cerebral autoimmune pathology. Differential diagnosis between Multiple Sclerosis and Systemic Lupus Erythematosus (clinical case). Congress dedicated to the 75th anniversary of the founding of the State University of Medicine and Pharmacy, USMF "Nicolae Testemitanu". Chisinau. 2020;3621-23.
Available:https://usmf.md/sites/default/files/inline-files/PROGRAM_16.10.2020-PROIECT-.pdf

Cojocaru V, Ceban E, Vasilieva Irina, Vasilieva Maria, et al. Derrote o mortal SARS-Cov-2 / COVID 2019. Published on LinkedIn. WAMS; 2020.

Cojocaru V, Ceban E, Vasilieva Irina, Vasilieva Maria, et al. Como testigo, salvando su propia vida del SARS-COV-2 / COVID19. Published on LinkedIn. WAMS; 2020.

Cojocaru V, Ceban E, Vasilieva Irina, Vasilieva Maria, et al. Tödliche β-SARS - Cov-2 COVID 19 ist noch kein Satz. Published on LinkedIn. WAMS; 2020.

Cojocaru V, Ceban E, Vasilieva Irina, Vasilieva Maria, et al. Mortel SARS - Cov-2 / COVID19 peut être vaincu. Published on LinkedIn. WAMS; 2020.

Cojocaru V, Ceban E, Vasilieva Irina, Vasilieva Maria et al. Successful resuscitation of deadly SARS - Cov-2 / COVID19. Bioinformatics & Proteomics Open Access Journal. 2020:4:1.
Available:https://medwinpublishers.com/BPOJ/successful-resuscitation-of-deadly-sars-cov2-covid19.pdf

Revenco N, Foca S, Jivalcovschi A, Ziaev L, et al. Challenges of pediatric multisystem inflammatory syndrome associated with COVID-19 - A Series of Clinical Cases. Biomedical Research and Clinical Reviews. 2020;4:1-3.
DOI: 10.31579/2692-9406/027

Vasilieva Maria. Biochemical quality changes in tears. Vinnitsa (Ukraine): XIY Materials at the International Student Conference. 2018;34-7.

Vasilieva Maria. Biochemical changes in the tear. Moldova USA: Days of the State University of Medicine and Pharmacy Nicolae Testemitanu. 2014;16.
Available:http://repository.usmf.md/handle/20.500.12710/6075