https://www.journaljamps.com/index.php/JAMPS/issue/feedJournal of Advances in Medical and Pharmaceutical Sciences2026-04-18T09:47:00+00:00Journal of Advances in Medical and Pharmaceutical Sciences[email protected]Open Journal Systems<p style="text-align: justify;"><strong>Journal of Advances in Medical and Pharmaceutical Sciences (ISSN: 2394-1111)</strong> aims to publish high quality papers (<a href="/index.php/JAMPS/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of Medical and Pharmaceutical Sciences. By not excluding papers based on novelty, this journal facilitates the research and wishes to publish papers as long as they are technically correct and scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled, OPEN peer-reviewed, open-access INTERNATIONAL journal.</p>https://www.journaljamps.com/index.php/JAMPS/article/view/858Recent Advances and Mechanistic Insights into Hydrotropic Solubilization: From Conventional Agents to Novel Combination Strategies2026-04-18T09:47:00+00:00G. W. Ugodi[email protected]E. C. Ezeamah<p>The poor aqueous solubility of emerging drug candidates remains a formidable challenge in pharmaceutical development, directly limiting oral bioavailability and therapeutic efficacy. Hydrotropic solubilization has gained significant attention as a versatile, cost-effective, and environmentally friendly technique to enhance the solubility of hydrophobic drugs without the need for organic solvents. This review provides a comprehensive overview of recent advances in the fundamental mechanisms underlying hydrotropy, including molecular self-aggregation, complexation, and the role of the Minimum Hydrotropic Concentration in initiating the solubilization process. The discussion categorizes hydrotropic agents into synthetic, natural, and novel classes, highlighting a strategic shift toward biocompatible and green alternatives. Findings from literature revealed recent advances in formulation strategies, such as the development of hydrotropic solid dispersions and mixed hydrotropy: a synergistic approach that achieves multifold solubility enhancement while minimizing individual agent concentrations and potential toxicity. By integrating advanced characterization techniques; including spectroscopic, microscopic, and thermodynamic studies with a critical analysis of regulatory and safety considerations for the commercialization of hydrotropic systems. These insights provide a structural framework for overcoming the solubility barrier and optimizing the delivery of next-generation therapeutic agents using hydrotropes.</p>2026-04-18T00:00:00+00:00Copyright (c) 2026 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.